Salicornia and its neuroprotective effect against diseases such as stroke

Original paper reference

• Original title: A Review on Polyphenols in Salicornia ramosissima with Special Emphasis on Their Beneficial Effects on Brain Ischemia
• Published in: Nutrients, 2023, Vol. 15, Artículo 793
• DOI: 10.3390/nu15030793

Paper abstract

This scientific review delves into the polyphenolic composition of Salicornia ramosissima, identifying more than 60 compounds with high bioactive value. The article particularly highlights the neuroprotective potential of these polyphenols against cerebral ischemia (stroke), based on preclinical studies.

The most relevant compounds include phenolic acids (such as ferulic, chlorogenic, gallic, caffeic, and vanillic acids) and flavonoids (such as quercetin, kaempferol, isoramnetin, rutin, and naringin), all of which have antioxidant, anti-inflammatory, and antiapoptotic effects. These compounds have been shown to reduce cerebral infarct volume, improve cognitive function, protect the blood-brain barrier, and mitigate neuronal inflammation.

Although human evidence is still limited, the use of Salicornia as a nutraceutical supplement is proposed to prevent brain damage and reduce the risk of neurovascular diseases.

Key points

• More than 60 polyphenols have been identified in Salicornia, with potent biological effects.
• Preclinical studies demonstrate its neuroprotective efficacy in animal models of stroke.
• Mechanisms of action include:
  • Reduction of oxidative stress and ROS.
  • Decreased inflammation and neuronal apoptosis.
  • Protection of the blood-brain barrier (BBB).
  • Improved cognitive and motor function post-stroke.
• Key compounds: quercetin, ferulic acid, chlorogenic acid, naringin, apigenin, catechin, rutin, taxifolin.
• Potential to regulate gut microbiota, which could indirectly contribute to brain health.
• High tolerability and safety in preclinical studies.
• Promising application in the development of nutraceuticals for stroke prevention.