Salicornia extract improves cardiovascular markers

Original paper reference

  • Original title: Dietary supplementation with polyphenol-rich Salicornia ramosissima extracts: Assessing safety, efficacy, and impact on cardiovascular health biomarkers in healthy volunteers
  • Published in: Journal of Functional Foods (2024), Vol. 122
  • DOI: 10.1016/j.jff.2024.106539

Paper abstract

This randomized, triple-blind, placebo-controlled clinical trial evaluated the effects of supplementation with polyphenol-rich extracts of Salicornia ramosissima (from salt marshes and hydroponically grown plants) in 90 healthy volunteers for three months. Supplementation with salt marsh Salicornia extract was found to be safe, well-tolerated, and beneficial for cardiovascular health.

The treatment significantly reduced levels of LDL cholesterol, homocysteine, and several plasma biomarkers associated with cardiovascular risk, such as MERTK, Gal-9, ADM, TF, among others. An increase in glomerular filtration rate and improved kidney function were also observed.

Key points

  • Triple-blind human clinical study with 90 participants.
  • Salicornia ramosissima from salt marshes showed a greater effect than Salicornia ramosissima grown hydroponically in freshwater cultures.
  • Significant reduction in LDL cholesterol and homocysteine, both associated with cardiovascular risk.
  • Positive modulation of biomarkers linked to inflammation, oxidative stress, and endothelial function.
  • No serious adverse effects were reported: only mild discomfort such as reflux or increased urination was reported.
  • Significant presence of caffeoylquinic acids, quercetin, and isoramnetin glycosides in the active extract.
  • Suggested diuretic and renal protective effects without affecting blood pressure.
  • Potential use as a preventative supplement for vascular and metabolic health.
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